Articles in MotW
Ruthenium(II) complexes of the general formula [(η6-arene)Ru(XY)Z]+ were studied for their anticancer properties in A2780 human ovarian cancer cells and A549 human lung cancer cells (Inorg. Chem. 2009, 48, 9444–9453, DOI: 10.1021/ic9013366). The specific arenes …
Organoruthenium complexes, of the form of [(η6-arene)RuII(YZ)X]+ (Inorg. Chem., 2008, 47, 11470–11486, DOI: 10.1021/ic801361m), are increasingly being studied for use in medicine. The arene is usually a phenyl derivative, YZ is usually a chelating ligand, …
Updated F 09.03.10 – As a reminder, you need to find three examples from the chemical literature (full papers, 2009 to present) that minimally include a molecular metal-ligand complex and a crystal structure. Send me …
Research involving the formation and characterization of high-valent Mn complexes has been slow. They are proposed to be active intermediates in biological and synthetic reactions, such as epoxidations and hydroxylations. They are also important intermediates …
Metal-DNA adducts are popular molecules for cancer treatment. However, the metal-based drugs have been associated with unwanted side effects such as nausea, nephrotoxicity (toxicity to kidney cells), and myelosuppression (suppression of bone marrow activity). Researchers …
The molecule for this week comes from research out of the Medicinal Inorganic Chemistry Group at the University of British Columbia in Vancouver and concerns altering pyridinone N-substituents to optimize activity as potential prodrugs for …
This article focuses on the synthesis of iron catalysts which are less toxic than those used in industry (Ryan J. Trovitch, Emil Lobkovsky, Marco W. Bouwkamp, Paul J. Chirik. Organometallics 2008 27, 6264-6278). Oxidative addition …
This week’s molecule comes from research at the University of Calabria, Italy about Pt(II) and Pd(II) complexes which may be active as anticancer agents (Pucci, D.; Bellusci, A.; Bernardini, S.; Bloise, R.; Crispini, A.; Federici, G.; …
The molecule of the week comes from ongoing research by Dr. Randolf Thummel at the University of Houston (Zeping Deng, Huan-Wei Tseng, Ruifa Zong, Dong Wang, and Randolph Thummel. Inorg. Chem. 2008, 47, 1835 – …
The molecule of the week is fresh out of Leiden University in the Netherlands regarding the cytotoxicity of fluorescent platinum (II) compounds (Brouwer, J.; den Dulk, H.; Kooijman, H.; Marques-Gellego, P.; Reekijk, J.; Roubeau, O.; …
Scientists at the University of Melbourne in Australia are currently doing research on Trianionic Organoborate triangles (Abrahams, B.F.; Boughton, B.A.; Choy, H.; Clarke, O.; Grannas, M.J.; Price, D.J.; Robson, R, Inorg. Chem. 2008, 47, 10.1021). …
So you’re working on your Molecule of the Week assignment and you’re looking at your molecule in Mercury and thinking Wow this is hideous. How am I going to make this look presentable? If you’re …
The molecule of the week originates from research at the Indian Institute of Science dealing with the photoactivation of oxovanadium complexes for photodynamic therapy (Sasmal, P.K.; Patra, A.K.; Nethaji, M. Chakravarty, A.R. Inorg. Chem. …
This week’s molecule comes out of recent research at Iowa State University focused on the catalytic activity of zirconium (IV) complexes involving a new class of scorpionate ligands (Dunne, J.F.; Su, J.; Ellern, A.; Sadow, …
After working through the assignment with a few test subjects (I mean beta testers! – thanks Nicole, Meghan, and Jon!), I’ve put together a more complete description.
Find an interesting molecule – it must contain a …
This website has been presented to me as a senior at Villanova Univeristy, someone who has taken a lot of undergraduate classes. I am a chemistry major, as are the other students in Dr. Kassel’s …
The molecule of the week comes from an article that focuses on alpha-Ketocarboxylates and structural models for certain types of halogenases (Friese, S. J.; Kucera, B. E.; Young, V. G., Jr.; Que, L., Jr.; Tolman, …
Initally, I was intimidated by this assignment. I don’t read science journals on a daily basis – actually I don’t really read them ever – and I was weary about where to begin. However, I …
